Core Nutritionals Soothe

COMPREHENSIVE INFLAMMATION MEDIATOR'

• Cissus quadrangularis - improved joint integrity and function.
• Boswellia - promotes healthy tendon and cartilage strength..
• Curcumin - suppresses pro-inflammatory compounds

Inflammation, aches and pains are an inescapable reality for anyone seriously engaged in bodybuilding or fitness. After all, building muscle literally involves tearing your own muscle fibers apart, forcing the body to respond with inflammation and pain. Yet the body doesn't always provide a proportional response and occasionally allows inflammation and pain to kick into overdrive. For some, the best approach to this is to be patient, let the body heal on its own time while dealing with the nagging injuries, aches and pain. For others, well, let's just say that some of us are unwilling to let anything stand in the way of our fitness goals. For those noble few, it's about pushing through the soreness as one more challenge to overcome, lest they miss out on further gains or fall behind the rest of the pack.

Cissus Quadrangularis Extract (stem) (5% ketosterones)

Cissus quadrangularis (CQ) is a plant with a long history of use in traditional and folk medicinal systems, including thousands of years of documented use in the Siddha and Ayurvedic traditions. While the specific use of Cissus in these systems varied, the most common traditional preparations related to analgesia, general tonics, and bone fracture healing. More recent research has developed physiological explanations for CQ’s traditional efficacy, including the reduction of pro-inflammatory cytokines, modulation of the glucocorticoid system (in animal trials), and the proliferation of osteoblast (bone-forming cell) DNA.

Specific to bone formation, there is strong data to suggest that CQ increases the accumulation of compounds known as mucopolysaccharides – long chain sugar molecules that precede mineralization in the process of bone formation. Think of these compounds sort of like the wet newspaper before it becomes paper mache. As stated, separate research also suggests that extracts of CQ stimulated osteoblastogenesis, the process of forming bone cells.

In relation to its positive effects toward certain inflammatory markers, which are key factors that contribute to osteoarthritis and bone damage, CQ (along with Withania somnifera) showed promise as a remedy in some animal studies. When the model was placed under an overabundance of oxidative stress and toxicity and cell death was high, the administration of CQ inhibited the gene expression of cytokines and matrix metalloproteinases, which are known to cause bone damage and cartilage aggravation. Additionally, CQ and the combination of W. somnifera, was shown to enhance cartilage tissue formation and positively impact osteoarthritis markers. These results provide positive validation to Cissus quadrangularis effectiveness in suppressing damaging inflammatory markers and being a potential therapeutic remedy for rheumatic and other joint disorders and conditions.

There have also been several human studies performed to validate CQ effectiveness. One study conducted on exercise trained men with joint pain showed that the administration of CQ was able to suppress inflammatory responses as well as improve markers of osteoarthritis.

Boswellia Extract (Boswellia serrate) (Gum resin) (65% boswellic acids)

Boswellia is a tree resin extract that is a traditional part of Indian medicine. In modern clinical trials the active agent, boswellic acid, and the gum resin it contains possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids, and four pentacyclic triterpenic acids, which are responsible for the inhibition of pro-inflammatory enzymes. Out of the four pentracyclic triterpenic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation. In human study’s, Boswellia has shown effectiveness in the managements of osteoarthritis and other joint related conditions. Several studies proved that Boswellia extract was effective at reducing pain and stiffness, increasing pain threshold, as well as improving overall joint function when compared to placebo. Similarly, to curcumin, boswellic acids have demonstrated a significant attenuation of NF-kB production in various animal and in vitro assays. Curcumin and Boswellia in combination as a treatment method for osteoarthritis has also showed beneficial results. One clinical human trial showed that this combination was able to increase the efficacy of osteoarthritis treatments due to its synergistic effects on oxidative stress reduction.

Curcumin (Curcuma longa) (95% Curcuminoids)

Curcumin, the primary polyphenol found in turmeric (a root known for its spice), has been the basis of many clinical studies for its therapeutic properties and ability to modulate multiple cells signaling pathways in certain inflammatory diseases known to humans.

Numerous studies seem to suggest that curcumin powerfully inhibits the enzymes that synthesize inflammatory compounds such as prostaglandins and leukotrienes. In particular, basic research and molecular studies have now firmly established curcumin’s ability to dose-dependently and potently inhibit a transcription factor known as NF–kB – a molecule involved in the proliferation of pro-inflammatory cytokines, soft tissue destruction, and autoimmune responses. Conditions where curcumin can provide benefit is in the management of certain metabolic diseases, anxiety, arthritis, and exercise induced inflammation that contributes to muscle damage and soreness. Most of curcumins benefits stem from its inflammation suppressing qualities along with potent antioxidant activity.

Studies have shown that low quality curcumin has low bioavailability and benefit, which is why we have used a high standard curcumin with 95% curcuminoids and have also included the trademarked Bioperine® in this formula. These two ingredients have a largely cohesive impact that can drastically improve the health benefit. Studies have shown that Bioperine® significantly improved curcumin uptake by upwards of 2000% at doses that proved to be clinically beneficial.

Gingever® (Zingiber officinale) (root) (Ginger Extract 10%)

Ginger is a flowering plant from the Zingiberaceae family with a lengthy history of culinary and medicinal use largely attributed to the therapeutic value of its antioxidant and anti-inflammatory properties.

Modern clinical trials have attributed the therapeutic benefits of ginger to its unique phytochemical substances (the biologically active organic compounds created by the plant) and its overall chemical composition. Ginger derives its anti-inflammatory effects from the non-volatile components found within the plant, specifically gingerols, shogaols, paradols, and zingerone. Studies have shown that these non-volatile compounds have anti-inflammatory properties with the potential to provide therapeutic relief for degenerative disorders such as arthritis and joint disorders, digestive distress, cardiovascular disorders, and other ailments. Likewise, the potent antioxidative properties of the non-volatile compounds found within ginger help alleviate age-related oxidative stress markers and have been shown to protect against ethanol-induced hepatotoxicity through suppression of oxidative stresses.

Research has also shown that ginger serves an effective inflammatory mediator able to decrease swelling, pain, and other inflammatory markers, especially with through the actions of [6]-gingerol. Here, data suggests that the anti-inflammatory action of ginger occurs through the inhibition of macrophage and neutrophil activation, as well as negatively affecting monocyte and leukocyte migration. According to the results of a study conducted on rats, there was a marked decrease in inflammatory cells infiltration and swelling, as well as an increase in antioxidant capacity, after the administration of ginger and its bioactive components. Core Nutritionals has chosen to use the patented Gingever® as its source of Ginger for Life Line’s Soothe as it is a highly potent extract consisting of 10% of these beneficial gingerols

Phyto-C™ (Acerola extract, blueberry, strawberry, maqui berry, acai, tart cherry, kale, broccoli, green tea extract, green coffee bean extract, turmeric extract)

Phyto-C™ is a trademarked complex blend of antioxidant rich superfoods clinically formulated to deliver a host of immune system supporting benefits. Combining ingredients such as blueberries, acai, tart cherry, kale, broccoli, green tea, turmeric, and others, you are ensuring that your body is being provided clinically proven and laboratory tested superfoods that will protect against free radicals and other cell destroying compounds. This neutralization of free radicals can protect vital cells, prevent illnesses, and reduce overall inflammation. Inflammation can disrupt normal cell processes thus leading to cell damage and disease. Inflammatory cells produce mediators such as cytokines, arachidonic acid, and other factors, which can precipitate a cascading negative reaction within the body. If this inflammation is not addressed in a reasonable manner, potentially permanent cell damage can occur. The key is to reach a point of equilibrium between free radical formation and antioxidant defense mechanisms. As a potent antioxidant source, Phyto-C™ can provide beneficial antioxidants for the body that can aid in this equilibrium and work to boost the immune system and overall health of the human body

Bioperine® (Black Pepper Extract) (Piper nigrum) (fruit) (std. to 95% Piperine)

BioPerine® is a patented standardized extract from the fruit of Piper nigrum (black pepper). It’s studied benefits have shown improvements in bioavailability of neighboring nutrients. When suppressing inflammation, overall efficiency and rapid delivery to the targeted cells have a multiplicative impact that enhances the overall therapeutic value of the administered compounds and nutrients. BioPerine® helps to increases the bioavailability and absorption of the aforementioned ingredients within Core Soothe.

BioPerine® primarily works through mechanisms and channels that can inhibit intestinal motility and dilate blood vessels of the intestines (where absorption of nutrients occurs). This physiological action may cause increased absorption and digestion of nutrients. Several studies looking at BioPerine® and its impact on nutrient absorption have been conducted with promising results. One study looking at the efficacy of BioPerine® on serum concentrations of curcumin showed bioavailability was improved by more than 500%. Therapeutic effectiveness of curcumin has often been exhibited as low. Another study conducted over the course of 6 weeks onBioPerine® influence on serum selenium levels in humans showed an increase by 145% over the presupplementation value.

With promising research being done on the effects of BioPerine® in the context of nutrient absorption and bioavailability, it is only fitting that we include it in Core Life Line’s inflammation suppressing product, Core Soothe.